Next week’s round of Champions League matches is highlighted by a clash of two clubs who have combined to win 16 European Cups as the most decorated sides in the history of this event.

Real Madrid vs AC Milan odds – Wednesday, October 21, 2:45 PM ET

Madrid is atop Group C with two wins in two matches, but they come into this match with injury worries. Cristiano Ronaldo had four goals in the first two matches, but he aggravated an ankle injury playing for his national team. Guti sprained his ankle in training and is working around the clock to get healthy. Still, Real has plenty of firepower with Karim Benzema and former Milan star Kaka.

Milan have split their first two Champions League matches, but like their Serie A star, they’ve struggled to score with just two goals. Filippo Inzaghi has scored both of those goals, meaning Milan needs help from the Brazilian duo of Ronaldinho and Alexander Pato. Their defense is still one of the best in Europe, but to gain maximum points, you need to find the back of the net.

Real will probably be favored at home at the Bernabeu, and they’ll have to show that they’re not completely dependent on Ronaldo, who has flourished since moving from Manchester United. Milan will aim to hit on the counterattack, and Real’s defense is just shaky enough that they may be able to sneak a goal out. However, it won’t be enough. Go with Real in your northbet.com sportsbook pick.